On-therapy isolates from 1 subject in viramune xr treatment group developed a novel amino acid substitution y181i and isolates from another subject in the immediate-release viramune treatment group developed a novel amino acid substitution y188n.
Information about Viramune.
Viramune should not be used as the sole active antiretroviralas monotherapy with any antiretroviral has shown to result in viral resistance.
Viramune is never taken on its ownIt must be taken with at least two other antiviral medicinesBecause the medicine can cause serious rashtreatment should be started at low doses.
Discontinue immediately with signs or symptoms of hepatitis or increased transaminase levels combined with rash or other systemic symptoms.
Risk of severelife threatening skin reactions including Stevens-Johnson syndrometoxic epidermal necrolysisand hypersensitivity.
Herbal preparations containing StJohn’s Wort and Viramune must not be co-administeredsee section 4.3If a patient is already taking StJohn’s Wort check nevirapine and if possible viral levels and stop StJohn’s WortNevirapine levels may increase on stopping StJohn’s WortThe dose of Viramune may need adjustingThe inducing effect may persist for at least 2 weeks after cessation of treatment with StJohn’s Wort.
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