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NOTESevere cardiopulmonary reactions have occurred when this drug has been given at greater than the recommended concentration and rate.
Like other antibiotics lincomycin can alter the normal bacteria in the colon and encourage overgrowth of some bacteria such as Clostridium difficile which causes inflammation of the colonpseudomembranous colitis
If significant diarrhea occurs during therapythis antibacterial should be discontinuedsee BOX WARNING
The preservative benzyl alcohol has been associated with serious adverse eventsincluding thegasping syndromeand death in pediatric patientsAlthough normal therapeutic doses of this product ordinarily deliver amounts of benzyl alcohol that are substantially lower than those reported in association with thegasping syndromethe minimum amount of benzyl alcohol at which toxicity may occur is not knownThe risk of benzyl alcohol toxicity depends on the quantity administered and the liver and kidneyscapacity to detoxify the chemicalPremature and low-birth weight infants may be more likely to develop toxicity.
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