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The metabolism of clopidogrel can also be impaired by drugs that inhibit CYP2C19such as omeprazole or esomeprazoleAvoid concomitant use of Plavix with omeprazole or esomeprazole because both significantly reduce the antiplatelet activity of Plavixsee DRUG INTERACTIONS
No dosage adjustment is necessary in patients with hepatic impairmentsee CLINICAL PHARMACOLOGY
The effect of Plavix did not differ significantly in various subgroupsas shown in Figure 3The benefits associated with Plavix were independent of the use of other acute and long-term cardiovascular therapiesincluding heparin/LMWHintravenous glycoprotein IIb/IIIaGPIIb/IIIainhibitorslipid-lowering drugsbeta-blockersand ACE inhibitorsThe efficacy of Plavix was observed independently of the dose of aspirin75-325 mg once dailyThe use of oral anticoagulantsnonstudy antiplatelet drugsand chronic NSAIDs was not allowed in CURE.
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