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Ethionamide may be bacteriostatic or bactericidal in actiondepending on the concentration of the drug attained at the site of infection and the susceptibility of the infecting organismEthionamidelike prothionamide and pyrazinamideis a nicotinic acid derivative related to isoniazidIt is thought that ethionamide undergoes intracellular modification and acts in a similar fashion to isoniazidIsoniazid inhibits the synthesis of mycoloic acidsan essential component of the bacterial cell wallSpecifically isoniazid inhibits InhAthe enoyl reductase from Mycobacterium tuberculosisby forming a covalent adduct with the NAD cofactorIt is the INH-NAD adduct that acts as a slowtight-binding competitive inhibitor of InhA.
Follow all directions on your prescription labelDo not take this medicine in larger or smaller amounts or for longer than recommended.
If you have an allergy to ethionamide or any other part of ethionamideIf you are allergic to any drugs like this oneany other drugsfoodsor other substancesTell your doctor about the allergy and what signs you hadlike rashhivesitchingshortness of breathwheezingcoughswelling of facelipstongueor throator any other signsIf you have liver disease.
Use ethionamide as ordered by your doctorRead all information given to youFollow all instructions closely.
Ethionamide may also be used for purposes not listed in this medication guide.
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