The safety and efficacy of clopidogrel have been evaluated in 5 double-blind studies involving over 88,000 patients the caprie study, a comparison of clopidogrel to asa, and the cure, clarity, commit and active-a studies comparing clopidogrel to placebo, both medicinal products given in combination with asa and other standard therapy.
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Gemfibrozil can increase the effect of the blood thinnerwarfarinCoumadinand thus may lead to bleedingThereforepatients on warfarin may need to have their doses of warfarin reduced when starting gemfibrozil.
Hematologiceosinophiliaanemiabone marrow hypoplasialeukopeniathrombocytopenia.
The effect of gemfibrozil in pregnant women has not been well-studiedGemfibrozil should be used during pregnancy only if the potential benefit justifies the unknown but potential risk to the fetus.
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