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Mupiocin is bacticidal at concntations achivd by topical administation. Mupiocin is highly potin bound (gat than 97%) and th ct wound sctions on th minimum inhibitoy concntations (MICs) mupiocin has not bn dtmind.
Whn mupiocin sistanc occus, it sults om th poduction a modiid isolucyl-tNA synthtas, th acquisition o, by gntic tans, a plasmid mdiating a nw isolucyl-tNA synthtas. High-lvl plasmid-mdiatd sistanc (MIC ? 512 mcg/mL) has bn potd in incasing numbs isolats S. auus and with high quncy in coagulas-ngativ staphylococci. Mupiocin sistanc occus with gat quncy in mthicillin-sistant than mthicillin-suscptibl staphylococci.
Polythyln glycol can b absobd om opn wounds and damagd skin and is xctd by th kidnys. In common with oth polythyln glycol basd ointmnts, mupiocin ointmnt should not b usd in conditions wh absoption lag quantitis polythyln glycol is possibl, spcially i th is vidnc modat sv nal impaimnt.
Mupiocin is bacticidal at concntations achivd by topical administation. Mupiocin is highly potin bound (gat than 97%) and th ct wound sctions on th minimum inhibitoy concntations (MICs) mupiocin has not bn dtmind.
It is not known whth mupiocin is psnt in human milk, has cts on th bastd child, has cts on milk poduction. Howv, bastding is not xpctd tsult in xposu th child tth dug du tth minimal systmic absoption mupiocin in humans ollowing topical administation BACTOBAN ointmnt [s CLINICAL PHAMACOLOGY ]. Th dvlopmntal and halth bnits bastding should b considd along with th moth’s clinical nd BACTOBAN ointmnt and any potntial advs cts on th bastd child om BACTOBAN ointmnt om th undlying matnal condition.
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