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However, parkinsonism and tardive dyskinesia often coexist in patients receiving Artane best Pills neuroleptic treatment, and anticholinergic therapy with ARTANE trihexyphenidyl may relieve some of these parkinsonism symptoms. ARTANE trihexyphenidyl is not recommended for use in patients with tardive dyskinesia unless they have Artane best Pills Parkinson’s disease.

Psychiatric disturbances can result from indiscriminate use leading to overdosage to sustain continued euphoria. As with other anticholinergics, trihexyphenidyl may cause suppression of lactation.

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Therefore, trihexyphenidyl should Artane best Pills be used if sophossearch.com expected benefit to the mother outweighs the potential risk to the infant. Pediatric Use Safety and effectiveness in pediatric patients have not been established. However, Artane Best Pills, rare cases of death associated with trihexyphenidyl overdosages taken in conjunction with other CNS-depressant agents have been reported or in patients with a compromised Artane best Pills condition. Trihexyphenidyl blood concentrations associated with the fatalities ranged from 0. Signs and Symptoms Overdosage with ARTANE trihexyphenidyl produces typical central symptoms of atropine intoxication the central anticholinergic syndrome. Correct diagnosis depends upon recognition of the peripheral signs of parasympathetic blockade, including dilated and sluggish pupils; warm, dry skin ; facial flushing; decreased secretions of the mouth, pharynx, nose, and bronchi ; foul-smelling breath; elevated temperature; tachycardia, cardiac arrhythmias; decreased bowel sounds ; and urinary retention.

Neuropsychiatric signs such as delirium, disorientation, anxiety, hallucinations, illusions, confusion, incoherence, agitation, hyperactivity, ataxia, lip smacking and tasting movements, loss of memory, paranoia, combativeness, and seizures may be present.

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The condition can progress to stupor, coma, paralysis, Artane Best Pills, Artane best Pills and respiratory arrest, and death. Treatment Treatment of acute overdose involves symptomatic and supportive therapy. Gastric lavage or other methods to limit absorption should be instituted.

Phenothiazines are contraindicated because the toxicity may be intensified due to their antimuscarinic action, causing coma. Respiratory support, Artane best Pills respiration or vasopressor agents may be necessary. Hyperpyrexia must be reversed, fluid volume replaced and acid-balance maintained. Urinary catheterization may be necessary.

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Artane trihexyphenidyl is also contraindicated in patients with narrow angle glaucoma, Artane Best Pills. Blindness Artane best Pills long-term use due to narrow angle glaucoma has been reported. It Artane best Pills has a relaxing effect on smooth musculature; exerted both directly upon the muscle tissue itself and indirectly through an inhibitory effect upon the parasympathetic nervous system. Its therapeutic properties are similar to those of atropine although undesirable side effects are ordinarily less frequent and severe than with the latter.

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