Among the people who should not take tetracycline are children younger than eight years of age and women who are pregnant or nursing.
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The hue and severity of tooth discoloration depend on four factors associated with tetracycline administration:
In this work is presented the processes of obtaining tetracyclinethe treatment of their waste and the environmental impact assessment of waste containing tetracycline.
Tetracyclines are broad spectrum antibiotics often used to treat skinchesturethraland pelvic infectionsDoxycycline is indicated in a wide range of infections including syphilisLyme diseaseQ feverRocky Mountain spotted feverand plagueIt is also widely used for malaria prophylaxis.
If you need to have any type of surgerytell the surgeon ahead of time that you are taking tetracyclineYou may need to stop using the medicine for a short time.
The most common mechanism by which microbes become resistant to tetracyclines is decreased accumulation of drug into previously susceptible organismsTwo mechanisms include 1impaired uptake into bacteriawhich occurs in mutant strains that do not have the necessary transport systemand 2the much more common plasmidor transposon-mediated acquisition of active efflux pumpsThe genomes for these capabilities may be transferred either by transductionas in Staphylococcus aureusor by conjugationas in many enterobacteriaA second mechanism of resistance is the production of aprotectiveprotein that acts by either preventing bindingdislodging the bound drugor altering the negative impact of binding on ribosomal functionAmong the tetracyclinestigecycline is characterized by less resistance due to efflux or ribosomal protectionRarelytetracyclines can be destroyed by acetylationResistance develops slowly in a multistep fashion but is widespread because of the extensive use of low concentrations of tetracyclines.
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