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For all HRTan excess risk becomes apparent within a few years of use and increases with the duration of intake but returns to baseline within a fewat most fiveyears after stopping treatment.
Increase or decrease in weightglucose intoleranceedemaarthralgiasleg crampschanges in libidourticariaexacerbation of asthmaincreased triglycerideshypersensitivity.
Estrogens may be poorly metabolized in women with impaired liver functionFor women with a history of cholestatic jaundice associated with past estrogen use or with pregnancycaution should be exercisedand in the case of recurrencemedication should be discontinued.
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