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The mechanism of action of REVIA in alcoholism is not understoodhoweverinvolvement of the endogenous opioid system is suggested by preclinical dataREVIAan opioid receptor antagonistcompetitively binds to such receptors and may block the effects of endogenous opioidsOpioid antagonists have been shown to reduce alcohol consumption by animalsand REVIA has been shown to reduce alcohol consumption in clinical studies.
Nose bleedsphlebitisedemaincreased blood pressurenon-specific ECG changespalpitationstachycardia.
Treatment in patients who have been able to abstain from alcohol in outpatient settings before treatment initiation.
Lethargy and somnolence have been reported following doses of REVIA and thioridazine.
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