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Administration of isotretinoin should be avoided shortly beforeduringand shortly after minocycline therapyEach drug alone has been associated with pseudotumor cerebriSee PRECAUTIONS
Reduce dose in renal impairmentconsider drug serum level determinations in prolonged therapy.
Intracranial hypertensionpseudotumor cerebrihas been associated with use of tetracyclines including minocyclineavoid concomitant use of isotretinoin and minocyclineisotretinoin is also known to cause pseudotumor cerebrialthough intracranial hypertension typically resolves after discontinuation of treatmentrisk of permanent visual loss existsseek ophthalmologic evaluation if visual disturbance occurs during treatmentsince intracranial pressure can remain elevated for weeks after drug cessationmonitor until patient stabilizes.
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