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Patients and caregivers should be advised that elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of deathPatients and caregivers should be advised that elderly patients with dementia-related psychosis treated with Zyprexa had a significantly higher incidence of cerebrovascular adverse eventse.gstroketransient ischemic attackcompared with placebo.

Possible risk factors for leukopenia/neutropenia include pre-existing low white blood cell countWBCand history of drug induced leukopenia/neutropeniaPatients with a history of a clinically significant low WBC or drug induced leukopenia/neutropenia should have their complete blood countCBCmonitored frequently during the first few months of therapy and discontinuation of Zyprexa should be considered at the first sign of a clinically significant decline in WBC in the absence of other causative factors.

Patients and caregivers should be counseled that a potentially fatal symptom complex sometimes referred to as NMS has been reported in association with administration of antipsychotic drugsincluding ZyprexaSigns and symptoms of NMS include hyperpyrexiamuscle rigidityaltered mental statusand evidence of autonomic instabilityirregular pulse or blood pressuretachycardiadiaphoresisand cardiac dysrhythmiasee Warnings and Precautions5.3

A Symbyaxolanzapine/fluoxetine HClis a fixed-dose combination of Zyprexa and fluoxetine.

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