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No dosage adjustment is necessary in patients with mild hepatic impairmentsee WARNINGS AND PRECAUTIONS

No dosage adjustment is necessary in patients with mild hepatic impairmentsee WARNINGS AND PRECAUTIONS

Some side effects of ezetimibe may occur that usually do not need medical attentionThese side effects may go away during treatment as your body adjusts to the medicineAlsoyour health care professional may be able to tell you about ways to prevent or reduce some of these side effectsCheck with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Ezetimibe does not inhibit cholesterol synthesis in the liveror increase bile acid excretionInsteadezetimibe localizes at the brush border of the small intestine and inhibits the absorption of cholesterolleading to a decrease in the delivery of intestinal cholesterol to the liverThis causes a reduction of hepatic cholesterol stores and an increase in clearance of cholesterol from the bloodthis distinct mechanism is complementary to that of statins and of fenofibratesee Clinical Studies

Additionallythe following side effects have been reported in general useallergic reactionswhich may require treatment right awayincluding swelling of the facelipstongueand/or throat that may cause difficulty in breathing or swallowingrashand hivesraised red rashsometimes with targetshaped lesionsjoint painmuscle achesalterations in some laboratory blood testsliver problemsstomach paininflammation of the pancreasnauseadizzinesstingling sensationdepressionheadachegallstonesinflammation of the gallbladder.

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