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A patient who had taken lovastatin and pravastatin on different occasions developed reversible impotenceThe impotence resolved within 2 weeks after the HMG-CoA reductase inhibitor was discontinuedRef]

Contraindicated with VYTORINsee CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS

Simvastatin has been associated with rare cases of severe myopathy and rhabdomyolysisThis is accompanied by elevations in creatine kinasemyoglobinuriaand proteinuriaas well as renal failureExperience with HMG-CoA reductase inhibitors indicates that concomitant use with gemfibrozilniacincyclosporineor erythromycin may increase the incidence and the severity of musculoskeletal side effects.

No incremental benefit of VYTORIN on cardiovascular morbidity and mortality over and above that demonstrated for simvastatin has been established.

Because the below reactions are reported voluntarily from a population of uncertain sizeit is generally not possible to reliably estimate their frequency or establish a causal relationship to drug exposure.

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