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Carbidopa allows patients treated for Parkinson’s disease to use much lower doses of levodopaSome patients who responded poorly to levodopa have improved on SINEMETThis is most likely due to decreased peripheral decarboxylation of levodopa caused by administration of carbidopa rather than by a primary effect of carbidopa on the nervous systemCarbidopa has not been shown to enhance the intrinsic efficacy of levodopa.

Be careful when driving or operating machinery until you know how SINEMET affects you.

Tell your doctor if you are taking any other medicinesincluding any that you buy without a prescription from your pharmacysupermarket or health food shopSome medicines and SINEMET may interfere with each otherThese include:

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