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Drug interactions may change how your medications work or increase your risk for serious side effectsThis document does not contain all possible drug interactionsKeep a list of all the products you useincluding prescription/nonprescription drugs and herbal productsand share it with your doctor and pharmacistDo not startstopor change the dosage of any medicines without your doctor’s approval.

1 These terms represent serious adverse reactionsbut do not meet the definition for adverse drug reactionsThey are included here because of their seriousness.

Patients should be cautioned about the risk of bleeding associated with the concomitant use of fluoxetine and NSAIDsaspirinwarfarinor other drugs that affect coagulationsee DRUG INTERACTIONS

Patients should be advised that taking SARAFEM can cause mild pupillary dilationwhich in susceptible individualscan lead to an episode of angle-closure glaucomaPre-existing glaucoma is almost always open-angle glaucoma because angle-closure glaucomawhen diagnosedcan be treated definitively with iridectomyOpen-angle glaucoma is not a risk factor for angle-closure glaucomaPatients may wish to be examined to determine whether they are susceptible to angle-closureand have a prophylactic proceduree.giridectomyif they are susceptiblesee WARNINGS AND PRECAUTIONS

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