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Metoclopramide increases the tone and amplitude of gastricespecially antralcontractionsrelaxes the pyloric sphincter and the duodenal bulband increases peristalsis of the duodenum and jejunum resulting in accelerated gastric emptying and intestinal transitIt increases the resting tone of the lower esophageal sphincterIt has littleif anyeffect on the motility of the colon or gallbladder.

A patient Medication Guide is available for Reglan InjectionThe prescriber or health professional should instruct patientstheir familiesand their caregivers to read the Medication Guide and should assist them in understanding its contentsPatients should be given the opportunity to discuss the contents of the Medication Guide and to obtain answers to any questions they may haveRefer to accompanying Medication Guide.

A few cases of neutropenialeukopeniaor agranulocytosisgenerally without clear-cut relationship to metoclopramideMethemoglobinemia in adults and especially with overdosage in neonatessee OVERDOSAGESulfhemoglobinemia in adults.

Stop using Reglan and call your doctor at once if you have tremors or uncontrolled muscle movementsfeverstiff musclesconfusionsweatingfast or uneven heartbeatsrapid breathingdepressed moodthoughts of suicide or hurting yourselfhallucinationsanxietyagitationseizureor jaundiceyellowing of your skin or eyes

Reglan is also used to treat gastroparesisslow stomach emptyingin people with diabeteswhich can cause heartburn and stomach discomfort after meals.

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