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Situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease processthe patient’s individual drug responsivenessand the effect of patient exposure to stressful situations not directly related to the disease entity under treatmentIn this latter situation it may be necessary to increase the dosage of the corticosteroid for a period of time consistent with the patient’s conditionIf after long-term therapy the drug is to be stoppedit is recommended that it be withdrawn gradually rather than abruptly.

EndocrineDecreased carbohydrate and glucose tolerancedevelopment of cushingoid statehyperglycemiaglycosuriahirsutismhypertrichosisincreased requirements for insulin or oral hypoglycemic agents in diabetesmanifestations of latent diabetes mellitusmenstrual irregularitiessecondary adrenocortical and pituitary unresponsivenessparticularly in times of stressas in traumasurgeryor illnesssuppression of growth in pediatric patients.

To induce a diuresis or remission of proteinuria in idiopathic nephrotic syndrome or that due to lupus erythematosus.

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