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During treatment with this medicationyou must drink more fluids than usual and pass urine frequently to help avoid kidney and bladder side effectsAsk your doctor how much you should drink and how often to empty your bladder each dayand follow these instructions carefully.

Treatment with cyclophosphamide may cause significant suppression of immune responsesSerioussometimes fatalinfections may develop in severely immunosuppressed patientsCyclophosphamide treatment may not be indicatedor should be interruptedor the dose reducedin patients who have or who develop viralbacterialfungalprotozoanor helminthic infections.

Caution is advised when using this drug in the elderly because they may be more sensitive to its effects.

Tell your doctor right away if any of these rare but very serious side effects occurblack/bloody stoolssevere stomach/abdominal painyellowing eyes or skindark urinemental/mood changesmuscle weakness/spasm.

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