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Table 3 gives the incidence of treatment-emergent adverse reactions in MDD and GAD placebo-controlled trials for approved indications that occurred in 2or more of patients treated with CYMBALTA and with an incidence greater than placebo.

The most common side effects of duloxetine are nauseadry mouthconstipationdiarrheafatiguedifficulty sleepingand dizzinessIncreased blood pressure can occur and should be monitoredSeizures have been reportedSexual dysfunctiondecreased sex drive and delayed orgasm and ejaculationhas been associated with duloxetine.

Cymbalta is used to treat major depressive disorder in adultsIt is also used to treat general anxiety disorder in adults and children who are at least 7 years old.

In rare casesa life-threatening condition called serotonin syndrome has occurred in patients who have taken CymbaltaSerotonin syndrome most often results when someone takes two or more medications that increase the body’s serotonin levels at the same timeYou need serotonin for your brain and nerve cells to functionbut too much of it can be dangerousSerotonin syndrome can lead to rapid changes in blood pressuremuscle rigidityseizuresand even death.

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