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Do not use an MAO inhibitor within 14 days before or 14 days after you take bupropionA dangerous drug interaction could occurMAO inhibitors include isocarboxazidlinezolidphenelzinerasagilineselegilineand tranylcypromine.

Coadministration of any other medications that contain bupropionbecause seizures are dose dependent.

Some patients who stopped smoking reported to have experienced symptoms of nicotine withdrawalincluding depressed mooddepressionrarely including suicidal ideationreported in smokers undergoing a smoking cessation attempt without medicationhoweversome of these adverse events occurred in patients taking bupropion who continued to smoke.

A manic episoderacing thoughtsincreased energyreckless behaviorfeeling extremely happy or irritabletalking more than usualsevere problems with sleep;

Seizure disorder or conditions that increase seizure riskarteriovenous malformationsevere head injuryCNS tumorCNS infectionsevere strokeanorexia nervosa or bulimiacurrent or prior diagnosis)

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